What we offer

Treatment for vaginal dryness, thinning skin, itchiness, painful sex, frequent UTIs, and urgency.

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Estrogen vaginal cream Rx

Treats moderate to severe vaginal dryness
  • Restores moisture
  • Results in 2-4 weeks
  • FDA-approved medication
Backed by decades of clinical studies, estrogen vaginal cream rebuilds skin and restores moisture. Regular use helps prevent common concerns like dryness, thinning skin, itchiness, pain with intimacy, and UTIs.
  • Estradiol 0.01%
    Generic of Estrace®
/2 mo
60 day supply
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Requires  one-time online medical consult. Includes 1 year of messaging and refills.

Order vaginal estrogen online

Get estrogen vaginal cream prescribed online, discreetly packaged, and delivered regularly to you.

Restore moisture
Soothe itching
Enjoy intimacy
Improve pelvic comfort

Join the club

90% of women report relief

Based on a review of vaginal estrogen by the American Journal of Gynecology and Obstetrics. Ghandi J, et al. AJOG. 2016;215(6):704-711.

How Interlude Works

Step 1

Convenient online visit

Place your order and take an online questionnaire. An MD will review and prescribe.

Step 2

Get free and fast shipping

Your vaginal estrogen prescription ships free to your door.

Step 3

Enjoy unlimited followups

Message an MD or GYN with questions at any time for free.

We care about sexual wellness. Expect to receive advice you can trust, 24/7 messaging, and prompt responses.

Add relief to your intimate skincare routine

01 Estradiol vaginal cream - Rx
Generic for Estrace, FDA-approved
02 Start your routine
Apply every night before bed for 2-4 weeks.
03 Then apply every 2-3 days
With consistent use, you'll feel results in 2-4 weeks with full benefits in 3 months.

Transparent pricing

At Interlude, our goal is to make our pricing as easy and comfortable as the care we offer.

Online visit fee
Easy online questionnaire
Reviewed by a licensed MD or GYN
Includes up to 1 year of refills
Treatment cost
/2 mo
60 day supply
Includes unlimited messaging and adjustments with our medical team
Refills delivered every 2 months with free shipping
Reschedule or cancel anytime

Get estrogen vaginal cream delivered today

Get expert care, the treatment you need, and relief in 2 weeks.


Read more FAQs here.

  • What is estrogen vaginal cream?

    Estrogen vaginal cream is a topical therapy that treats changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by declining estrogen levels from menopause. These changes are also known as vulvovaginal atrophy or the genitourinary syndrome of menopause (GSM).

  • How does estrogen vaginal cream work?

    Estrogen vaginal cream restores the skin in and around the vagina.

  • Does estrogen vaginal cream really work?

    Clinical studies have shown that up to 90% of women who use estrogen vaginal cream report subjective relief. The 2022 hormone therapy position of The North American Menopause Society states: "For bothersome genitourinary syndrome of menopause symptoms not relieved with over-the-counter therapies in women without indications for use of systemic hormone therapy, low-dose vaginal estrogen therapy or other therapies (eg, vaginal dehydroepiandrosterone or oral ospemifene) are recommended."

  • How do I use estrogen vaginal cream?

    Estrogen vaginal cream is typically applied every day for 2 weeks and then every 2-3 days thereafter. Follow the specific boxed instructions and the instructions from your medical provider.

  • Does estrogen vaginal cream have any side effects?

    Data from the Women's Health Initiative Observational Studyshowed that for postmenopausal women who used vaginal estrogen, the risk of invasive breast cancer, colorectal cancer, endometrial cancer, stroke, and blood clots was the same as those that did not. The boxed safety information for Estrace® vaginal cream shows that there is an increased risk of these conditions, however women's health groups state that these warnings do not apply to vaginal estradiol cream and they have been lobbying the FDA to remove the warning.

  • What causes vaginal atrophy (VA) or the genitourinary syndrome of menopause (GSM)?
    The vulva, vagina, urethra, labia, bladder, and sexual organs are tissues in the body that exist because they contain estrogen. When your ovaries stop producing estrogen beginning in perimenopause, these tissues begin to atrophy. (We hate that word as much as you do. But atrophy is normal. And we're here to tell you that treatment is normal too.)
  • What is vaginal atrophy (VA) or the genitourinary syndrome of menopause (GSM)?
    Also known as vulvar vaginal atrophy (VVA) or the genitourinary symptoms of menopause (GSM), vaginal atrophy is when the tissues feel dry, thin, too tight, or tender. You may notice changes in the shape of your vulva. You may even experience bleeding. As the tissues change due to lack of estrogen, the vagina produces less mositure, the vaginal canal shrinks, the vaginal folds lose elasticity, sexual organs become less prominent, blood flow and nerve sensation is reduced, and the urethra is exposed to abrasion and infection. This leads to painful sex, frequent UTIs, urgency to pee, yeast infections, loss of sexual pleasure, and discomfort in everyday activities. (Even wiping with toilet paper can be painful!)
  • How long does it take to start feeling relief?
    Results are typically experienced within two to four weeks of treatment. If symptoms are not beginning to subside after six to eight weeks, talk to your Interlude clinician. You may need a dose increase or adjustment. Checkins and messaging are included with your treatment and we look forward to helping you with any questions that come up.
  • How do I sign up?

    To get started you'll create a secure account and complete payment. Then you'll take an online assessment that will be reviewed by our medical team. A licensed MD or GYN will create a prescription and care plan that's customized to your needs.

    We are currently offering your first two months of prescription treatment for . After that, we'll ship refills for every two months. Your initial treatment requires a one-time online visit fee. Unlimited messaging and free shipping are included in your care with us.

  • Do you take insurance?
    We do not accept insurance at this time. However, with rising out of pocket costs, high deductible plans, and high co-pays in the traditional health care system - Interlude is more affordable and accessible for most women - with or without insurance.
  • What's the best way to pay with HSA or FSA?
    First, check the balance on your FSA or HSA account and that your plan covers prescription treatment through Interlude. You can place an order online, using your FSA or HSA card (as you would any other credit card), or by calling our Customer Care Team for assistance at (909) 378-6899, Monday to Friday 9AM - 5PM Pacific Standard Time.