Treatment for vaginal dryness, painful sex, frequent UTIs, and urgency.
Treatment for vaginal dryness, painful sex, frequent UTIs, and urgency.
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We offer estradiol vaginal cream 0.01% which is an FDA-approved generic medication. Each tube contains 42.5 grams of cream.
Each gram of cream contains 0.1 mg estradiol in a nonliquefying base containing purified water, propylene glycol, stearyl alcohol, white ceresin wax, mono- and di-glycerides, hypromellose 2208 (4000 cps), sodium lauryl sulfate, methylparaben, edetate di-sodium and tertiary-butylhydroquinone.
This cream comes with a reusable plastic applicator, and can also be applied with a fingertip. The standard dose is to apply daily at bedtime for two weeks, and then taper to twice weekly. With ongoing use, you'll improve the health of the vagina, urethra, and bladder and prevent bothersome symptoms.
To avoid exposing a sexual partner to this medication, avoid sexual intercourse immediately after applying.
Vaginal estrogen treatment is beneficial because it releases a very low dose of estrogen directly into the vaginal area, without being absorbed significantly throughout the body. This means vaginal estrogen has fewer side effects and is a safe option, even for women who do not want or cannot take other forms of menopause hormone therapy.
There is no evidence that vaginal estrogen increases the risk of cancer, cardiovascular disease, stroke, dementia, or any other serious problems.
At Interlude, we offer estradiol vaginal cream that's bioidentical and FDA-approved. This means you'll receive medication that's been rigorously tested for safety and efficacy, and that ships from a US-regulated pharmacy.
You can start to notice improvement within two weeks. It may take up to 3 months to notice full benefits.
Use of vaginal estrogen treatment has been shown to:
You can use vaginal estrogen as long as needed to prevent symptoms from returning. There is no age limit.
As estrogen levels decline, the vulva, vagina, urethra, and bladder become thin and dry. Vaginal estrogen works to restore the health of the tissues and prevent issues like dryness, painful sex, unusual odor, and urgency.
Offered as an estradiol vaginal cream or suppository, low-dose vaginal estrogen therapy is the gold standard for restoring the function of your vagina, bladder, and urinary tract. You'll need a prescription but we make that part super easy with an online consult for estradiol vaginal cream and delivery to your door.
At Interlude, our goal is to make our pricing as easy and comfortable as the care we offer.
Get expert care, the treatment you need, and relief in 2 weeks.
Read more FAQs here.
Estrogen vaginal cream is a topical therapy that treats changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by declining estrogen levels from menopause. These changes are also known as vulvovaginal atrophy or the genitourinary syndrome of menopause (GSM).
Improvement is noticed starting in the first month, with a slower progressive improvement for the following 24 months.
Estradiol vaginal cream helps prevent vaginal and urinary discomfort due to menopause (genitourinary syndrome of menopause). Use of estradiol vaginal cream has been shown to:
Estradiol vaginal cream restores the skin in and around the vagina.
Clinical studies have shown that up to 90% of women who use estrogen vaginal cream report subjective relief.
The North American Menopause Society stated in 2022: "For bothersome genitourinary syndrome of menopause symptoms not relieved with over-the-counter therapies in women without indications for use of systemic hormone therapy, low-dose vaginal estrogen therapy or other therapies (eg, vaginal dehydroepiandrosterone) are recommended."
Estrogen vaginal cream is typically applied every day for 2 weeks and then every 2-3 days thereafter. Follow the specific boxed instructions and the instructions from your medical provider.
Data from the Women's Health Initiative Observational Study showed that for postmenopausal women who used vaginal estrogen, the risk of invasive breast cancer, colorectal cancer, endometrial cancer, stroke, and blood clots was the same as those that did not. The boxed safety information for estradiol vaginal cream shows that there is an increased risk of these conditions, however women's health groups state that these warnings do not apply to vaginal estradiol cream and they have been lobbying the FDA to remove the warning.
The vulva, vagina, urethra, labia, bladder, and sexual organs are tissues in the body that exist because they contain estrogen. When your ovaries stop producing estrogen beginning in perimenopause, these tissues begin to atrophy. (We hate that word as much as you do. But atrophy is normal. And we're here to tell you that treatment is normal too.)
Also known as vulvar vaginal atrophy (VVA) or the genitourinary symptoms of menopause (GSM), vaginal atrophy is when the tissues feel dry, thin, too tight, or tender. You may notice changes in the shape of your vulva. You may even experience bleeding.
As the tissues change due to lack of estrogen, the vagina produces less mositure, the vaginal canal shrinks, the vaginal folds lose elasticity, sexual organs become less prominent, blood flow and nerve sensation is reduced, and the urethra is exposed to abrasion and infection.
This leads to painful sex, frequent UTIs, urgency to pee, yeast infections, loss of sexual pleasure, and discomfort in everyday activities. (Even wiping with toilet paper can be painful!)
To get started you'll create a secure account and complete payment. Then you'll take an online assessment that will be reviewed by our medical team. A licensed MD or GYN will create a prescription and care plan that's customized to your needs.
We are currently offering your first two months of prescription treatment for . After that, we'll ship refills for every two months. Your initial treatment requires a one-time online visit fee. Unlimited messaging and free shipping are included in your care with us.
We do not accept insurance at this time. However, with rising out of pocket costs, high deductible plans, and high co-pays in the traditional health care system - Interlude is more affordable and accessible for most women - with or without insurance.
First, check the balance on your FSA or HSA account and that your plan covers prescription treatment through Interlude. You can place an order online, using your FSA or HSA card (as you would any other credit card), or by calling our Customer Care Team for assistance at (909) 378-6899, Monday to Friday 9AM - 5PM Pacific Standard Time.
