Treatment for vaginal dryness, painful sex, frequent UTIs, and urgency.
Treatment for vaginal dryness, painful sex, frequent UTIs, and urgency.
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We offer estradiol vaginal inserts (10 mcg) which is an FDA-approved generic of Vagifem. Each box contains 18 pre-filled applicators.
Each insert contains 10 mcg of estradiol, with inactive ingredients including starch, corn, hypromellose, lactose monohydrate, magnesium stearate, and polyethylene glycol.
Each applicator is pre-filled with a vaginal estrogen insert that contains 10 mcg of estradiol. This tiny and fast-dissolving tablet is inserted with a hygienic plastic applicator. The plastic applicator is discarded after use
The common dose is to apply daily at bedtime for two weeks, and then taper to twice weekly. Follow the instructions from your Interlude-affiliate prescribing physician.
Vaginal estrogen treatment is beneficial because it releases a very low dose of estrogen directly into the vaginal area, without being absorbed significantly throughout the body. This means vaginal estrogen has fewer side effects and is a safe option, even for women who do not want or cannot take other forms of estrogen hormones.
There is no evidence that vaginal estrogen increases the risk of cancer, cardiovascular disease, stroke, dementia, or any other serious problems.
At Interlude, we offer estradiol vaginal inserts (10 mcg), which is an FDA-approved generic medication. This means you'll receive medication that's been rigorously tested for safety and efficacy, and that ships from a US-regulated pharmacy.
You can start to notice improvement within two weeks. It may take up to 3 months to notice full benefits.
Use of vaginal estrogen treatment has been shown to:
Vaginal estrogen can be used as long as needed to prevent symptoms from returning. There is no age limit.
As estrogen levels decline, the vulva, vagina, urethra, and bladder become thin and dry. Vaginal estrogen works to restore the health of the tissues and can help prevent urinary urgency, frequency, leakage, vaginal dryness, painful sex, and frequent UTIs.
Offered as an estradiol vaginal insert or cream, low-dose vaginal estrogen therapy is the gold standard for restoring the function of your vagina, bladder, and urinary tract. You'll need a prescription but we make that part super easy with an online consult for estradiol vaginal inserts and delivery to your door.
At Interlude, our goal is to make our pricing as easy and comfortable as the care we offer.
Get expert care, the treatment you need, and relief in 2 weeks.
Read more FAQs here.
Vaginal estrogen helps prevent vaginal and urinary symptoms due to menopause (genitourinary syndrome of menopause). Use of vaginal estrogen has been shown to:
Vaginal estrogen is typically offered as a cream or suppository and delivers a low dose of estrogen directly where it's needed without being absorbed significantly throughout the body. At Interlude, we offer a range of vaginal estrogen options with prescription included.
Improvement is usually noticed starting in the first month, with a slower progressive improvement for the following 24 months.
Estradiol vaginal inserts (10 mcg) are a simple way to use vaginal estrogen without the mess of creams. Each insert comes in its own pre-filled, disposable applicator. No measuring, no mess, no applicator to wash. Dissolves quickly and is free of the parabens and sulfates found in the generic estradiol vaginal cream.
Vaginal estrogen is a low-dose and localized treatment that isn’t shown to elevate risk of serious side effects. However, many women are rightfully concerned when using any form of estrogen hormone treatment.
It’s confusing because when you open your box of vaginal estrogen, you will read a black box warning label that says estrogen increases risk of certain cancers and other side effects. The leaflet is based on systemic estrogen, and not vaginal estrogen.
The FDA is working to update this label to reduce confusion. In the meantime, we have an in-depth article on this topic: What we know about vaginal estrogen, including side effects and risks.
Lastly, if you are a patient with us and you’re concerned about potential side effects, you can message your doctor through your secure account. They’ll be happy to help discuss any concerns with you.
Many women are rightfully concerned about breast cancer risk with any kind of estrogen. But what sets vaginal estrogen apart is its localized nature and lower systemic absorption.
It's reassuring that there is general consensus among gynecologists and oncologists that even women with a history of breast cancer can take vaginal estrogen. However, anyone with a history of breast cancer should first consult their oncologist about it.
To learn more, read our in-depth article on vaginal estrogen and cancer risk.
The vulva, vagina, urethra, labia, bladder, and sexual organs are tissues in the body that exist because they contain estrogen. When your ovaries stop producing estrogen beginning in perimenopause, these tissues begin to lose their structure. Symptoms tend to get worse with time and without treatment, which is why you're likely to experience these symptoms even well after menopause.
No, there is no age limit to using vaginal estrogen.
To get started you'll first select which vaginal estrogen product you'd like to try. Then you'll create a secure account and complete payment. Then you'll take an online assessment that will be reviewed by our medical team. A licensed MD or GYN will create a prescription and follow up by secure message or video.
We are currently offering your first two months of prescription treatment for . Your initial treatment requires a one-time online visit fee.
For refill shipments you can always bundle your shipments and save. Refills are $89/box for 3 boxes, $99/box for 2 boxes, or $109 for 1 box.
Unlimited messaging with your prescribing physician and free shipping are included in your care with us.
We do not accept insurance at this time. However, with rising out of pocket costs, high deductible plans, and insurance high co-pays, Interlude is more affordable and accessible for most women - with or without insurance.
Yes! You can place an order online, using your FSA or HSA card (as you would any other credit card). We can also help assist with any reimbursement - just call our support team for assistance at (909) 378-6899, Monday to Friday 10AM - 5PM Pacific Standard Time.
