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Treatment for vaginal dryness, painful sex, frequent UTIs, and urgency.


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Vaginal estradiol
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Estradiol vaginal suppositories Rx

Treat vaginal symptoms caused by menopause
  • Results in 2-4 weeks
  • FDA-approved medication
Treats and prevents vaginal dryness, itching, burning, frequent UTIs, and/or urgency to pee caused by menopause. 90% of women report subjective relief from their symptoms.
  • 18 vaginal inserts
  • Estradiol 10mcg
  • With disposable applicators
60 day supply
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Free shipping. Cancel anytime.
  • Meet estradiol
    • Bio-identical
    • Derived from plants
    • Each insert contains 10mcg of estradiol
    Treats menopause symptoms:
    • Vaginal dryness, itching, and burning
    • Pain with sex
    • Frequent UTIs
    • Urgency to pee
  • How it works
    • Apply before bed every night for 2-4 weeks until natural moisture is restored
    • After that, use every 3-4 days to maintain results
    • Refills ship every 60 days (or at your selected frequency)
    • Cancel or reschedule any time
    • Your first box of vaginal estradiol suppositories is
    • Refills ship for with free shipping
  • Side effects
    Vaginal estrogen has not been shown to cause serious side effects. Read the boxed safety information for more information about estrogens.
Requires  one-time online medical consult. Includes 1 year of messaging and refills. Cancel or reschedule at any time.

How Interlude Works

Step 1

Get started with a prescription

Complete an online medical form with information about your symptoms and health history.

Online medical consultation for vaginal dryness
Step 2

Our doctors review your info

Within hours, we'll follow up by phone, video, or secure chat and write a prescription if appropriate.

Doctor prescribing vaginal estradiol patient who has vaginal atrophy from menopause
Step 3

Free delivery to your door

Your vaginal estradiol ships free with discreet packaging.

Vaginal estradiol delivered in a discreet box with free shipping


24/7 medical support.

Chat with our medical team at any time.

How to use estradiol vaginal suppositories

This tiny and fast-dissolving tablet is inserted with a hygienic plastic applicator.
To get started, apply every night before bed for 2-4 weeks.
Then apply every 3-4 days. With ongoing use, you'll prevent further dryness, irritation, thinning, and atrophy.

Benefits of vaginal estrogen

As estrogen levels decline in menopause, vaginal estrogen works to restore the health of the tissues in the vagina and vulva. Prescription treatment can help target your sexual wellness goals:

Restore moisture
Soothe itching
Enjoy intimacy
Improve pelvic comfort
Woman smiling because she is experiencing relief from menopause symptoms


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Transparent pricing

At Interlude, our goal is to make our pricing as easy and comfortable as the care we offer.

Online visit fee
Easy online questionnaire
Reviewed by a licensed MD or GYN
Includes up to 1 year of refills
Treatment cost
60 day supply
Includes unlimited messaging and adjustments with our medical team
Refills delivered every 2 months with free shipping
Reschedule or cancel anytime

Get estradiol vaginal suppositories prescribed & shipped today

Get expert care, the treatment you need, and relief in 2 weeks.

Order now


Read more FAQs here.

  • What is vaginal estradiol?

    Vaginal estradiol treats changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by declining estrogen levels from menopause. These changes are also known as vulvovaginal atrophy or the genitourinary syndrome of menopause (GSM).

  • How long does it take for vaginal estradiol to work?

    Improvement is noticed starting in the first month, with a slower progressive improvement for the following 24 months.

    • Within one month: Vaginal moisture is noticeably restored and vaginal tissues are noticeably healthier
    • Within 3-4 months: Maximum vaginal moisture is restored
    • Within 24 months: Vaginal pH returns to normal levels

  • What are the benefits of vaginal estradiol?

    Vaginal estradiol helps prevent vaginal and urinary discomfort due to menopause (genitourinary syndrome of menopause). Use of vaginal estradiol has been shown to:

    • Restore moisture and flexibility to the vaginal tissues
    • Normalize vaginal pH
    • Reduce pain with sex
    • Prevent UTIs
    • Prevent incontinence

  • Does vaginal estradiol really work?

    Vaginal estradiol restores the skin in and around the vagina.

    Clinical studies have shown that up to 90% of women who use vaginal estradiol report subjective relief.

    The North American Menopause Society stated in 2022: "For bothersome genitourinary syndrome of menopause symptoms not relieved with over-the-counter therapies in women without indications for use of systemic hormone therapy, low-dose vaginal estrogen therapy or other therapies (eg, vaginal dehydroepiandrosterone) are recommended."

  • How do I use vaginal estradiol?

    Vaginal estradiol is typically applied every day for 2 weeks and then every 3-4 days thereafter. Follow the specific boxed instructions and the instructions from your medical provider.

  • Does vaginal estradiol have any side effects?

    Data from the Women's Health Initiative Observational Studyshowed that for postmenopausal women who used vaginal estrogen, the risk of invasive breast cancer, colorectal cancer, endometrial cancer, stroke, and blood clots was the same as those that did not. The boxed safety information for vaginal estradiol shows that there is an increased risk of these conditions, however women's health groups state that these warnings do not apply to vaginal estradiol and they have been lobbying the FDA to remove the warning.

  • What causes vaginal atrophy (VA) or the genitourinary syndrome of menopause (GSM)?

    The vulva, vagina, urethra, labia, bladder, and sexual organs are tissues in the body that exist because they contain estrogen. When your ovaries stop producing estrogen beginning in perimenopause, these tissues begin to atrophy. (We hate that word as much as you do. But atrophy is normal. And we're here to tell you that treatment is normal too.)

  • What is vaginal atrophy (VA) or the genitourinary syndrome of menopause (GSM)?

    Also known as vulvar vaginal atrophy (VVA) or the genitourinary symptoms of menopause (GSM), vaginal atrophy is when the tissues feel dry, thin, too tight, or tender. You may notice changes in the shape of your vulva. You may even experience bleeding.

    As the tissues change due to lack of estrogen, the vagina produces less mositure, the vaginal canal shrinks, the vaginal folds lose elasticity, sexual organs become less prominent, blood flow and nerve sensation is reduced, and the urethra is exposed to abrasion and infection.

    This leads to painful sex, frequent UTIs, urgency to pee, yeast infections, loss of sexual pleasure, and discomfort in everyday activities. (Even wiping with toilet paper can be painful!)

  • How do I sign up?

    To get started you'll create a secure account and complete payment. Then you'll take an online assessment that will be reviewed by our medical team. A licensed MD or GYN will create a prescription and care plan that's customized to your needs.

    We are currently offering your first two months of prescription treatment for . After that, we'll ship refills for every two months. Your initial treatment requires a one-time online visit fee. Unlimited messaging and free shipping are included in your care with us.

  • Do you take insurance?

    We do not accept insurance at this time. However, with rising out of pocket costs, high deductible plans, and high co-pays in the traditional health care system - Interlude is more affordable and accessible for most women - with or without insurance.

  • What's the best way to pay with HSA or FSA?

    First, check the balance on your FSA or HSA account and that your plan covers prescription treatment through Interlude. You can place an order online, using your FSA or HSA card (as you would any other credit card), or by calling our Customer Care Team for assistance at (909) 378-6899, Monday to Friday 9AM - 5PM Pacific Standard Time.

Reviews for estradiol vaginal suppositories (10mcg)

Reviews represent individual experiences and may not reflect clinical results. Individual results may vary.
Estradiol vaginal suppositories
Estradiol vaginal suppositories (10 mcg)