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Vaginal estradiol cream

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Restore comfort, moisture, and intimacy.

Feel good about you. Our care plans include FDA-approved medications, caring providers, and fast and free delivery.

Get relief today
*Requires online visit reviewed by an MD. Includes unlimited messaging and refills for up to one year.

Health meet care

Your goals and our expert care are a winning combo. Get a care plan and FDA-approved medication to target your goals:

Enjoy intimacy
Prevent UTIs
Improve pelvic comfort
Soothe itching
Reduce urgency
Restore moisture

How Interlude works

Step 1

Take the online assessment

Answer questions about your symptoms and medical history.

Step 2

Get estradiol vaginal cream

We'll create a custom prescription and deliver refills every two months.

Step 3

Ask us anything anytime

Our MDs and OBGYNs are here to answer any questions that come up.

Get an essential and simple routine

We've got you covered with the right care plan for your concerns.

01 Estradiol vaginal cream - Rx
Generic for Estrace, FDA-approved
02 Start your routine
Apply every night before bed for 2-4 weeks.
03 Then apply every 2-3 days
With consistent use, you'll feel results in 2-4 weeks with full benefits in 3 months.

Designed just for you

Your health is our goal.

This treatment changed my life. I could see the skin color coming back to pink, I had sexual desire, and I no longer have UTIs.

See May's care plan

Not sure what to expect when you get your care plan? We'll show you! Enter your email and we'll send you Interlude CEO May's actual plan.

Read up on her goals, prescription, ingredients, routine, and safety information.

Got it! Check your email to see May's care plan.

Get started today

Try a 2 month supply for , plus a one-time consult fee.

2 month
supply

Estradiol cream

Try 2 months for . After that, we'll deliver refills every 2 months for .

Free
3-5 day
shipping

Automatic refills

You can reschedule your shipment at any time from your secure account.

Free
Unlimited
messaging

Here when you need us

We're here for you to answer questions or make adjustments.

Questions?

Read more FAQs here.

  • Who is Interlude for?

    If you are looking for specialized care for common menopause and post-menopause concerns, then Interlude is the place for you. Our team of medical specialists are experts in helping women to restore vaginal moisture, enjoy intimacy, prevent frequent UTIs, and stop urgent peeing.

  • What is the genitourinary syndrome of menopause (GSM)?
    Also known as vulvar vaginal atrophy (VVA) or the genitourinary symptoms of menopause (GSM), vaginal atrophy is when the tissues feel dry, thin, too tight, or tender. You may notice changes in the shape of your vulva. You may even experience bleeding. As the tissues change due to lack of estrogen, the vagina produces less mositure, the vaginal canal shrinks, the vaginal folds lose elasticity, the clitoris becomes less prominent, blood flow and nerve sensation is reduced, and the urethra is exposed to abrasion and infection. This leads to painful sex, frequent UTIs, urgency to pee, yeast infections, loss of sexual pleasure, and discomfort in everyday activities. (Even wiping with toilet paper can be painful!)
  • What treatments does Interlude offer for GSM?
    We primarily offer vaginal estradiol cream. The North American Menopause Society states in 2020: "For bothersome genitourinary syndrome of menopause symptoms not relieved with over-the-counter therapies in women without indications for use of systemic hormone therapy, low-dose vaginal estrogen therapy or other therapies (eg, vaginal dehydroepiandrosterone or oral ospemifene) are recommended."
  • How long does it take to start feeling relief?
    Results are typically experienced within six to eight weeks of treatment. If symptoms are not beginning to subside after six to eight weeks, talk to your Interlude clinician. You may need a dose increase or adjustment. Checkins and messaging are included with your treatment and we look forward to helping you with any questions that come up.
  • How do I sign up?

    To get started you'll create a secure account and complete payment. Then you'll take an online assessment that will be reviewed by our medical team. A licensed MD or GYN will create a prescription and care plan that's customized to your needs.

    We are currently offering your first two months of prescription treatment for $15. After that, we'll ship refills for $59 every two months. Your initial treatment requires a one-time $69 online visit fee. Unlimited messaging and free shipping are included in your care with us.

  • Do you take insurance?
    Due to government regulation for telemedicine, we do not accept insurance at this time. However, with rising out of pocket costs, high deductible plans, and high co-pays in the traditional health care system - our medical care is more affordable and accessible for most women - with or without insurance.