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Treatment for vaginal dryness, painful sex, frequent UTIs, and urgency.


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Estradiol Plus Cream
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Soothing Estradiol Cream

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Soothe your skin while repairing signs of vaginal dryness. Prescribed after a simple consultation with a qualified doctor, our Soothing Estradiol Cream combines clinically-proven estradiol with soothing ingredients like hyaluronic acid, aloe, and vitamin E for sensitive skin. It's gentle, effective, and free from harsh additives.
Save $20 on your first order
  • 1 tube
  • 32 grams
$69 $49
Save $20
  • Online consult and prescription
  • One-time fee
Free shipping. Cancel anytime.

Medication information

  • What are the key ingredients?

    Our Soothing Estradiol Cream contains the following ingredients:

    • Estradiol treats vaginal dryness, itching, or burning.
    • Hyaluronic Acid is used to help retain moisture in the skin and relieves dryness.
    • Aloe moisturizes and soothes skin.
    • Vitamin E lessens dryness.

    Your formula will contain an ultra-low dose of estradiol, a bioidentical form of estrogen.

    Your formula is freshly compounded in a 503A compounding pharmacy with PCAB Accreditation.

  • How do I use this cream?

    This cream comes in an easy-to-use dispenser with a snap-on applicator. Just snap on the applicator, turn and click the dispenser, and then tilt off the applicator.

    The common dose is to insert 1-2 grams vaginally daily for 2 weeks. After that, insert 1 gram vaginally 1 to 3 times per week. 1 gram is 4 clicks.

    Follow the instructions from your Interlude-affiliated prescribing doctor.

  • Who is this cream for?

    Our Soothing Estradiol Cream is for women who want to treat signs of vaginal dryness from perimenopause and menopause.

    When estradiol is applied vaginally, it's shown to help improve symptoms that can result from dryness - including renewing vaginal moisture, restoring skin elasticity, eliminating painful sex, reducing UTIs, and lessening urinary urgency and incontinence.

  • When will I notice results?

    With consistent use, many patients notice a difference within 2 weeks. But everyone is different - so results may vary. Keep in mind this is not just about relief, but repairing the skin. It's not an overnight fix. Use as directed by your Interlude-affiliated doctor for lasting results!

Reviews

We're rated Excellent on Trustpilot.

How It Works

Step 1

Complete your visit

After you complete checkout, you'll fill out a short health profile. Our medical team will review it to ensure you receive safe and effective care.
Interlude questionnaire form on a mobile phone
Step 2

Freshly compounded

Clinically-proven ingredients are freshly compounded just before shipping to you.
A board-certified physician working with Interlude
Step 3

Free delivery to your door

We'll ship your order directly to you, with ingredients that you can't get over-the-counter or in standard pharmacies.

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24/7 support

Questions? Just ask us! We're here for you. You can message our medical team at any time.

Order your Soothing Estradiol Cream today

Free shipping with expedited options available.

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